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KMID : 0388120130220010021
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Journal of Korean Society for the Study of Obesity
2013 Volume.22 No. 1 p.21 ~ p.29
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The Association between Serum Gamma-glutamyltransferase within Normal Range and Risk Factors of Cardiovascular Diseases: Based on the Framingham Risk Score
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Koh Hae-Jin
Choi Chang-Su
Youn Chang-Ho
Lee Duk-Hee
Lee Sung-Guk
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Abstract
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Background: We investigated the association between serum GGT level with risk factors of cardiovascular diseases and the Framingham risk score (FRS).
Methods: A Total of 712 subjects (men 160, women 552) were enrolled, excluding 296 subjects either having any of hepatic diseases, taking medications that could affect liver function, having abnormal liver function, or drinking alcohol excessively. We classified the subjects into terciles according to the serum GGT levels. We analyzed the differences and trends of clinical characteristics between the three groups, and the correlation between serum GGT level and FRS.
Results: As the serum GGT level increased, there was an increases in blood pressure, body mass index, total cholesterol, triglyceride, fasting glucose, and FRS in women, whereas only triglyceride and FRS increased in men (P < 0.05). Multivariate regression analysis was performed after adjusting for BMI and waist circumferences with FRS as the dependent variable. The results showed positive association between GGT and FRS in both men and women, which were statistically significant (β = 0.632, P = 0.011 in men; β = 0.769, P = 0.004 in women).
Conclusion: There was a positive association between serum GGT level within normal range and Framingham risk scores. Serum GGT level may be considered as a useful biomarker to estimate the risks of cardiovascular diseases.
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KEYWORD
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Cardiovascular diseases, Framingham risk score, Gamma-glutamyltransferase, GGT, Risk factors
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